Chrome DevTools has a feature called blackboxing which allows you to ignore certain scripts when debugging. When a script is blackboxed, it's hidden from the call stack pane and you don't step into it when stepping through the code. This is really useful when debugging code that uses frameworks or libraries such as Ember, React or jQuery.
A really useful feature that I often find myself using in Chrome DevTools is conditional breakpoints. Conditional breakponts allow you to only pause execution when a certain expression evaluates to true, meaning that you can pause it when you want it to.